Grapefruit Essential Oil for Lowering Hypertension and Reduce Appetite

An interesting study from the Journal of Brain Research published in 2005 and republished in the archives of the National Institute of Health shows that the inhalation of grapefruit essential oil has the effect of lowering blood pressure in rats. Conducted by the Division of Protein Metabolism, Institute for Protein Research at the Osaka University, the following abstract describes the study and the effects of the olfactory stimulation on adrenalin nervous system. It was also found to decrease appetite. The benefits were attributed to the active compound limonene. The action was through direct action on the central histamine nerves of the brain.

To enjoy the benefits of grapefruit for hypertension or appetite craving, eat a grapefruit. Or for a more routine effort, simply take a bottle of grapefruit essential oil and open the bottle wave it under your nose and inhale. Try this when craving food or when you suspect your blood pressure may be on the rise.

Olfactory stimulation with scent of essential oil of grapefruit affects autonomic neurotransmission and blood pressure.


Here, we show that olfactory stimulation with SGFO for 10 min elevates renal sympathetic nerve activity (RSNA) and blood pressure (BP) and lowers GVNA in urethane-anesthetized rats. Olfactory stimulation with limonene, a major component of grapefruit oil, also elicited increases in RSNA and BP in urethane-anesthetized rats. Anosmic treatment with ZnSO(4) eliminated both the effects of SGFO and scent of limonene on RSNA and BP. Intracerebral administration of diphenhydramine, a histaminergic H1-antagonist, abolished SGFO- or scent of limonene-mediated increases in RSNA and BP as well as the decrease in GVNA. Moreover, bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) eliminated the SGFO- and limonene-mediated increases in RSNA and BP and decrease in GVNA, but bilateral lesions of the cerebral cortex did not have any affect on these parameters. These findings suggest that scent ofgrapefruit oil and its active component, limonene, affect autonomic neurotransmission and blood pressure through central histaminergic nerves and the suprachiasmatic nucleus.